I'm right handed but I find when using emulators and such that using WASD for movement and the arrow keys for the action buttons is by far the best for comfort. In the history of game controllers, where was the directional pad/analog stick? on the left side. And actions on the right.
But yeah, not really related to your question but,,, next time you guys run Zsnes or whatever, try WASD for movement and arrow keys for actions. Q and E I usually use for L and R. I find that I can play pretty much as easily with or without a gamepad using this method.