Before flaming me about "not being able to make a poll about this shit without adding EVERY game in the catagory" thing, hear me out.
The nintendo DS only had 4 rated M DS titles, and each are pretty decent :o
From the good port of Resident Evil, to the bloody horrors of Dementium the Ward.
Which M rated game however, is the best in your opinion?
2005's Resident Evil Deadly Silence?

First person knife combat was pretty cool
Touch The Dead?

Nothin like ol' fasion rail shooting eh?
Dementium: The Ward?

Most think it is impossible to run a 60 fps game on a DS, they are "dead" wrong! XD(just had to, could not resist :P)
or Mortal Combat DS?

acually its a port of the classic mortal combat 3, but with some gimmicks and wifi play!
pick your poison >:3