After a cursory search of topics I was surprised to see no mention of Venture Bros.! Basically it's a hilariously badass cartoon that follows the wacky adventures of a pill-popping neurotic SUPER-scientist, his two reject sons and their secret agent bodyguard. Setup sound familiar to anyone? Well if it does, that's because it parodies and pays homage to old school pulp-comics, mystery and adventure cartoons like Johnny Quest, Tin-Tin and Scooby Doo.

It's one of those really tongue in cheek comedic cartoons with allusions, pop references and constant satire of the adventure/comic book genre. It's really well done IMO and has continuing story arcs, great characters and actual continuity. I'd recommend it to those who like action/adventure cartoons, have a weird sense of humor, or both.
Check Cartoon Network, Teletoon or Bravo for airings and Season 1 and 2 are on DVD. (Plus youtube and those other places)