Yeah, I'm pretty sure I've done this naturally before, just by going to work, partying all night, having to work the next morning, then just not getting around to sleeping until much later.
However, I think I've surpassed the 48 (maybe closer to 50-60) hour mark with the assisstance of Adderall. I took a good dose two days in a row and didn't even think about sleeping. Towards the end, my mind was just haywire, extremely fatigued, even if my body wanted to keep on. I remember lying in bed with the lights on, playing Gameboy, waiting for some wave of physical fatigue to take me to sleep, but it didn't happen until much later. After a while, I started to hear conversations in my head. Also, I'd get visions of movement in the corner of my eye where there was nothing. It's not really vivid hallucinations, just your mind under a lot of stress, definitely not enjoyable.