I'm about 23 hours in and counting on my first play through.
Despite some glitches, after all it is from BUGthesda, I've been having a pretty fun time in this game. Overall the feel is still very Fallout, although there are a couple points where you're outside of the radio station's range and the ambient music track comes in - a bit too Oblivion-ish. The pose with the game's sword weapons is a bit familiar as well.
The V.A.T.S targeting works really well, and if you have the stats for it, combat becomes fun and in many cases, funny. I was getting my ass handed to me early on by Raiders with combat shotguns. Solution? Shoot the weapon out of their hand first, then beat them to death with a baseball bat to conserve ammo. The A.I. seems to anticipate this later on...there are bodies and discarded weapons around - you shoot the weapon away from your target only to see him/her/it scramble for a suitable replacement. Nice touch. I used to get concerned facing an enemy packing grenades, now I smile. Target the grenade and blow it up in the enemy's hand...or better yet, wait until it is thrown - pop into V.A.T.S and detonate it in the air...over the heads of a couple of enemy mercs. Another nice touch.
In one area, I set a bunch of mines in a choke point, and then used some gunfire to draw the enemy to my position. It worked like a charm.
I don't know if it is a fault or a credit, but when I went on walkabout, I actually jumped ahead in the main quest line because I stumbled onto the location of a major character.
Also, thus far I've found Dogmeat to be pretty handy to have around - though I haven't tested his find ability out yet. I leave him behind when I'm trying to pure stealth, because he has a habit of running towards the nearest super mutant, growling and snapping - and me being a dog person, I abandon my slow crouch and charge up right after him, machine gun blazing, to keep him from getting blown away or smeared by a super-sledge.
For me, aiming has been working outside of V.A.T.S. just fine. I get critical/crippling hits on super mutants when I tag them in the head with a hunting rifle, I've shot off limbs with the shotgun, etc.
Vagrancy - Be careful who you wake up in a twenty four hour parking lot.
His name was Not Johnny - A young man becomes a sort of superhero after a crippling injury. He