My guy in Mass Effect is so powerful now that killing anything is pathetically easy. I've beat the game three times with him now, and the last time the final boss was about as difficult as a Geth Colossus. I love the game, but having played it four times now, starting over with a new character just feels so tedious.
I'm playing Fallout 3 now (PC), and it's been a lot of fun so far. It's amazing seeing every pile of rubble looking different, rather than the same pile over and over, just rotated or a slightly different shade or color. I like this game a lot more than Oblivion because the decisions you make actually make a difference, and you can be noticeably evil.
Oblivion was fun for the combat, but the hideously ugly NPCs, the total lack of a diverging plot, and lame character interactions give the game no replayability. I played the game from start to finish within about two days, and every time I've tried to go back to it, I realize how crappy it really was.
Anyway, now Fable 2 is on the 360, and I've been hearing good stuff about it. I hope this comes out on the PC really soon because I want to play it.