Melatonin regulates the sleep cycle. If your endocrine system has become compromised or if your melatonin production itself is out of whack (staring at any source of light past your bedtime will cause this, IE computer monitor, as production is linked intimately with light perception) then you will probably not sleep normally and likely will develop some form of insomnia. (as if there is more than one kind.)

Not getting adequate sleep = greater chance of tumor growth caused by stress. Not to mention that your endocrine system produces many chemicals that simply inhibit tumor growth from the get go. Your thyroid is part of the endocrine system, for example. Having hyper/hypothyroidism as a result of a non optimal pineal gland efficiency would likely also be a factor in determining cellular health and possibly even the lifespan of an organism.

Bonus Info:

Melatonin is produced in the pineal gland, a small pine-cone shaped (hence, the name) organ near the base of your brain. The pineal gland is outside of the blood brain barrier, thus it is easily affected by free radical oxidation that is part of the "normal aging process." Heavy metals in particular tend to accumulate there, so it it important to keep your system well maintained by ingesting plenty of nutrient-rich foods and brightly colored vegetables and fruits that are high in antioxidants and other free radical scavenging molecules.

http://en.wikipedia.org/wiki/Melatonin

The dark side of light at night: physiological, epidemiological,
and ecological consequences http://www.psy.ohio-state.edu/nelson/documents/JPinealRes2007.pdf

Epidemiology of urinary melatonin in women and its relation to other hormones and night work.
http://www.ncbi.nlm.nih.gov/pubmed/15184249

yah

unrelated, I am growing reishi mushrooms to treat arthritis in addition to my normal psilocybin-based treatment and whole heartily recommend it to all emotionally stable, healthy, sane, internet nerds out there.

wait

yeah dude ive tripped a couple times before. this is probably gonna be one of my bigger doses though (3.5 grams, splitting a quarter with someone) so im excited

also how is MDMA? ive been interested in trying it but ive heard its DaNgErOuS

Its the main ingredient in ecstacy but when taken pure it feels alot better. I haven't gotten my hands on the pure stuff yet but I've taken some really good ex. I don't imagine theres much a difference to the regular rolling. Also its like anything else you're taking the dangerous thing about taking mdma is suffering from dehydration, alot of people take it while raving and because it causes your body heat to crank up and alot of sweating it can drain your fluids fast. Get a bunch of orange juice and sip on that shit while you're rolling and its supposed to help keep the feeling strong. Also make sure you get some gum or something to chew on while you're doing it or you're going to be grinding your teeth.

And it feels like being on a roller coaster at the top of a really big drop down, that racing and excited feeling you get and just being that way for hours. Plus a general feeling of I CAN TAKE THE WORLD and free love. I've heard the comedown can be pretty rough sometimes though so you'd prolly wanna get ready for that. But I've never been too bothered by it then again I haven't taken pure rolls.

basically what buttkiller said, lots of loud music, lights, and you're really really really gonna wanna fuck. You can actually last AWHILE on that shit and makes sex better.

Despite all of the good things I said about it, rolling alot isn't something you'd wanna do. its a party drug, you take it and party and then stop taking it for awhile or bad things are bound to happen.

come to boulder pure MDMA is common as dirt around here

it's actually a big problem; kids this age feel fucking invincible, they do not consider what that shit does to your body at all. i was in this category for a couple of months... i would basically do some form of molly prior to just about every concert i went to. i go to quite a few concerts, and it just doesn't feel that bad for you when you do it. my doses were not particularly high, but it's just not a good idea to set into those sort of habits without catching yourself, at least for a while

yeah dude, definitely. The people I know that do it and myself included keep it to infrequent occasions, its one of those things you do when you wanna go out and pretty much treat yourself.

its like dem chocolate don't eat lot off chocolate or u get fat an stoopid

But don't drink too much or you'll drop the electrolyte levels in your blood.

Smoking is awful for you, but listerine strips and menthol cigarettes are probably the best thing ever on a good roll

Pure mdma feels great, but the day after is fucking awful so take the next days schedule into consideration and pop a couple 5htp supplement capsules before you go to sleep

Also, don't do drugs. They're not good for you

I am a sociopath, I have the ability to feel guilt, it's not feeling any guilt I have a problem with, what is your point

anything to take off the pain

A group of British scientists and pharmacologists recently completed an in-depth study on the 20 most harmful drugs in British society and the results were fairly interesting; I figure this is relevant due to the ecstasy discussion.

1. Heroin
2. Cocaine
3. Barbituates
4. Methadone
5. Alcohol
6. Ketamine
7. Benzodiazepines
8. Amphetamines/Speed (but not Ice/Meth)
9. Tobacco
10. Buprenorphine (an opiate, it's used in the UK for getting people off heroin)
11. Cannabis (the newer research on this was a bit worrying in a few ways)
12. Solvents
13. 4MTA
14. LSD
15. Methylphenidate (Ritalin)
16. Anabolic Steroids
17. GHB
18. Ecstasy
19. Alkyl Nitrites (Poppers)
20. Khat

I found it interesting that they essentially said that Ecstasy isn't very harmful if used in moderation - a lot of it has to do with the stigma surrounding it. The main problem I have with the list is inhalants/solvents being number 12 - that shit is not cool and not safe in any way.

And before people come in and go WEED ISN'T DANGEROUS its caused a lot of problems for me and some other people I know, so yeah, it can be.

Also I think the reason Ice isn't on there is because it hasn't really 'hit' the UK like it has in America and Australia, otherwise I'm sure it'd be top 3.

but then that word "moderation" comes into effect. If you moderate your weed use you aren't as likely to get paranoia or anxiety or whatever its causing just as much as you aren't as likely to get fucked up off coke or ecstacy if you use it in moderation.

I think weed just got so high on the list because of its more widespread use than ecstacy and that people when using it don't usually tend to moderate themselves nearly as much. I might be wrong though cus I didn't read the study and you did.

Interesting Ptizzle.  There is also this:

also I can def see why methadone is so high on that list, that shit is a killer.

yeah my dad got addicted to that shit for years while trying to kick heroin. he said the withdrawl was waaaaay worse than from heroin

1. Anybody try firecrackers? I have a little bud left and was thinkin bout doin that.

2. Monetary consequences aside, if you ingest cannabis instead of smoke it, aren't there no negative health side effects?

3. Is it true that cannabis is good for cancer treatment? I see a lot of stuff around, mostly that it is good to stimulate the appetite for chemo patients and possibly pain relief/nausea treatment. But, do cannabinoids specifically bind to tumor sites, causing apoptosis of cancerous cells?