OK so I've used it pretty much non-stop since release, and gave it some time just to get used to it, and here would be a list of problems with it for me anyways:
-Fails to render certain buttons in the right spots, generally the ones that are for like "browse..." or "choose file...". It displays the button inside the bar that shows the directory to the file. For the record, it doesn't even DISPLAY that bar sometimes, like in the GW Uploader.

-It is forced to render the whole site before loading it, unlike FireFox which displays whatever it has rendered (afaik). This is a problem because I've had an adserver fail to send me its ad in Chrome, and as a result the site never loaded for me.
-The Phishing & Malware option uses up a lot of RAM, though I have plenty so this doesn't matter to me, it could really cripple lower end PCs which don't have as much (I have 4GB)
-There's no option to choose PHISHING ONLY or MALWARE ONLY. (to lower your PC's resource usage)
-There's no option to only send crash reports and not stats. It's both or none. This wouldn't be much of a problem for me if it was complete ass to send a crash log manually.
-Sometimes the tabs bug out if you open too many too fast, the words in the tab will all be the same, even if they are actually different processes.
-Sometimes it isn't just a name and all the tabs will become the same process for no reason at all.
-Skin changes when you restart it after the first time, no option to go back to it from fitting whatever you have.
-It's based on some Netscape code and not Mozilla's XPI so stuff like AdBlock isn't possible apparently (wikipedia says so.) (But since it's open source someone will fix this I know it.)
-No option to mask as other browsers, which sucks for banking sites etc.
That's really all the problems I have with it.